By a macro-level feature, I understand any feature that supervenes on, and is thus realized in, lower-level features. Recent discussions by Kim have suggested that such features cannot be causally relevant insofar as they are not classically reducible to lower-level features. This seems to render macro-level features causally irrelevant. I defend the causal relevance of some such features. Such features have been thought causally relevant in many examples that have underpinned philosophical work on causality. Additionally, in certain typical biological cases, we conceive of causally relevant features at various compatible levels of analysis. When elaborated, these points make a strong prima facie case for macro-level causal relevance. However, we might abandon both the philosophical guideposts and the corresponding explanatory practice in the special sciences were we convinced that no reflective philosophical account could provide for the causal relevance there supposed. I show that such drastic measures are not necessary, for we can make sense of macro-level causal relevance by drawing on Paul Humphreys' recent work in ways suggested by the concrete examples considered here.